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IgG4 Food Antibodies [ELISA]

GC Labs code	G152	Test Field	Immunology

GC Labs code

G152

Test Field

Immunology

Information

Test method	ELISA (Enzyme linked immunosorbent assay)
Specimen (mL)	S 0.5
Specimen storage	Refrigerated
Specimen stability	Refrigerated (7 days)
Test schedule	Mon-Fri
Analytical time (day)	3

Test method

ELISA (Enzyme linked immunosorbent assay)

Specimen (mL)

S 0.5

Specimen storage

Refrigerated

Specimen stability

Refrigerated (7 days)

Test schedule

Mon-Fri

Analytical time (day)

Reference range/Unit	[Serum] See comments in the report
Clinical Significance	This test measures specific IgG4 antibodies against food antigens that may cause food intolerance. It examines IgG4 antibodies for 90 types of foods commonly consumed by Koreans. Unlike IgE, IgG4 is not considered a mediator of acute allergic reactions, but rather a reflection of the body’s response to continuous exposure to allergens. Generally, the presence of specific IgG4 antibodies is interpreted as an immune response to the corresponding food and subsequent development of tolerance. However, in certain conditions such as eosinophilic esophagitis, IgG4 has been reported to act as a pathogenic factor that can worsen symptoms. To identify the cause of an acute allergic reaction to a specific food, specific IgE testing is essential and should be performed prior to IgG4 testing. Nevertheless, in cases of chronic allergic conditions, IgG4 testing can be helpful in identifying potential allergenic foods and understanding the patient’s immune status. It may also indicate which foods should be avoided when symptoms occur.
Compulsory forms
Remark	① Hemolyzed specimen is unsuitable ② Since the test cannot be performed when taking immunosuppressive drugs such as Cortisone (corticosteroids), an examinee can take the test after stopping taking the drug for 60 days

Reference range/Unit

 [Serum]
See comments in the report

Clinical Significance

This test measures specific IgG4 antibodies against food antigens that may cause food intolerance. It examines IgG4 antibodies for 90 types of foods commonly consumed by Koreans. Unlike IgE, IgG4 is not considered a mediator of acute allergic reactions, but rather a reflection of the body’s response to continuous exposure to allergens. Generally, the presence of specific IgG4 antibodies is interpreted as an immune response to the corresponding food and subsequent development of tolerance. However, in certain conditions such as eosinophilic esophagitis, IgG4 has been reported to act as a pathogenic factor that can worsen symptoms.
To identify the cause of an acute allergic reaction to a specific food, specific IgE testing is essential and should be performed prior to IgG4 testing. Nevertheless, in cases of chronic allergic conditions, IgG4 testing can be helpful in identifying potential allergenic foods and understanding the patient’s immune status. It may also indicate which foods should be avoided when symptoms occur.

Compulsory forms

Remark

① Hemolyzed specimen is unsuitable
② Since the test cannot be performed when taking immunosuppressive drugs such as Cortisone (corticosteroids), an examinee can take the test after stopping taking the drug for 60 days