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Aldosterone [LC-MS/MS]

GC Labs code	N882	Test Field	Endocrinology

GC Labs code

N882

Test Field

Endocrinology

Information

Test method	LC-MS/MS (Liquid chromatography-MS/MS)
Specimen (mL)	S 1.0 EDTA P 1.0
Specimen storage	Frozen
Specimen stability	Frozen (14 days)
Test schedule	Mon-Fri
Analytical time (day)	3

Test method

LC-MS/MS (Liquid chromatography-MS/MS)

Specimen (mL)

S 1.0
EDTA P 1.0

Specimen storage

Frozen

Specimen stability

Frozen (14 days)

Test schedule

Mon-Fri

Analytical time (day)

Reference range/Unit	[Plasma] 0.0 ~ 30.0 (ng/dL) [Serum] 0.0 ~ 30.0 (ng/dL)
Clinical Significance	Approximately 1-2% of individuals with primary hypertension have primary hyperaldosteronism characterized by hypokalemia (low potassium) and low direct renin. Because serum aldosterone concentrations vary due to dietary sodium intake and body positions, some physicians prefer measurement of 24-hour urine concentrations for aldosterone.
Compulsory forms
Remark	[Specimen handling method] ① Recommended to collect specimen in the morning - It tends to be measured higher in the morning than afternoon ② Dietary factor of pseudohyperaldosteronism - Licorice (Licorice-containing candies, drinks, chewing gum, and tea), grapefruit and carbenoxolone, etc. - Especially, the intake of licorice should be avoided for at least 2 weeks before performing a test ③ Effects of diet and body posture - High/low sodium diet, stress and strenuous exercise should be avoided - Consistent posture should be maintained before and during blood collection (It tends to be measured at a concentration 2 to 3 times higher in standing posture than supine posture) ④ Drug effects - The use of non-steroidal anti-inflammatory drugs (NSAIDs: Ibuprofen, etc.), diuretics, beta-antagonist, steroids, angiotensin-converting enzyme inhibitor, and oral contraceptives affects test results [Precautions] After collection, centrifuge immediately and store frozen

Reference range/Unit

 [Plasma]
0.0 ~ 30.0 (ng/dL)

 [Serum]
0.0 ~ 30.0 (ng/dL)

Clinical Significance

Approximately 1-2% of individuals with primary hypertension have primary hyperaldosteronism characterized by hypokalemia (low potassium) and low direct renin. Because serum aldosterone concentrations vary due to dietary sodium intake and body positions, some physicians prefer measurement of 24-hour urine concentrations for aldosterone.

Compulsory forms

Remark

[Specimen handling method]
① Recommended to collect specimen in the morning
- It tends to be measured higher in the morning than afternoon
② Dietary factor of pseudohyperaldosteronism
- Licorice (Licorice-containing candies, drinks, chewing gum, and tea), grapefruit and carbenoxolone, etc.
- Especially, the intake of licorice should be avoided for at least 2 weeks before performing a test
③ Effects of diet and body posture
- High/low sodium diet, stress and strenuous exercise should be avoided
- Consistent posture should be maintained before and during blood collection (It tends to be measured at a concentration 2 to 3 times higher in standing posture than supine posture)
④ Drug effects
- The use of non-steroidal anti-inflammatory drugs (NSAIDs: Ibuprofen, etc.), diuretics, beta-antagonist, steroids, angiotensin-converting enzyme inhibitor, and oral contraceptives affects test results

[Precautions]
After collection, centrifuge immediately and store frozen