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Disease-Based Test Panel

Osteoporosis

1) Core items
Test code Test name Clinical description
C404 25-Hydroxyvitamin D (25 OH Vitamin D) Assessment of vitamin D deficiency and calcium absorption
C547 Bone alkaline phosphatase [S] Bone formation marker; assessment of bone formation activity
S641 C-terminal telopeptides (CTX) Bone resorption marker; assessment of the degree of bone loss
E412 Intact parathyroid hormone (PTH) Evaluation of parathyroid function (assessment of secondary osteoporosis)
K662 Osteocalcin Reference marker for predicting treatment response reflecting osteoblast activity
2) Optional items
Test code Test name Clinical description
S735 Deoxypyridinoline (DPD) Urine-based bone resorption marker reflecting osteoclast activity
E427 Estradiol (E2) Differential diagnosis of secondary osteoporosis due to sex hormone deficiency
Z003 N-terminal telopeptide (NTx) Assessment of the degree of bone resorption
L959 Testosterone Differential diagnosis of secondary osteoporosis due to sex hormone deficiency
N935 Total procollagen-type 1 N-terminal propeptide (total P1NP) Bone formation marker used for estimation of fracture risk
3) Supplementary items
Test code Test name Clinical description
C104 Alkaline Phosphatase (ALP) Reference marker in the presence of abnormal liver function in addition to bone metabolism
C154 Calcium, Total [S] Assessment of calcium levels related to bone metabolism
C448 Magnesium (Mg) [S] Adjunct marker for bone metabolism
C158 Phosphorus (Inorganic) Assessment of inorganic phosphorus levels related to bone metabolism and renal function
4) Diagnostic workflow and Test utilization for Osteoporosis
Disease Primary test Secondary test Supplementary test
Osteoporosis screening 25-OH Vitamin D, CTx, Bone ALP Osteocalcin, P1NP Calcium, Phosphorus, Mg
Fracture risk assessment Bone ALP, CTx, Vitamin D NTx, P1NP ALP, Creatinine
Differential diagnosis of secondary osteoporosis Intact PTH, Vitamin D TSH, Cortisol, Testosterone/Estrogen Electrolyte test
Monitoring of treatment response in osteoporosis Bone ALP, CTx, P1NP Osteocalcin, Deoxypyridinoline Vitamin D, Mg, ALP